Confocal image showing the distribution of the AMPA receptor GluR2 subunit in Purkinje cells from wild-type mouse cerebellar slices. Research from the labs of Rick Huganir and David Linden has shown that mice harboring mutations in GluR2 that interfere with regulated binding of the protein PICK1 interfere with cerebellar long-term depression (LTD), a cellular model system of motor memory.

Steinberg et al., Neuron 49: 845 (2006)