Johns Hopkins University, Department of Neuroscience
 

 

 

 

George  Uhl, MD, Ph.D

Associate Professor of Neurology

Telephone Number:   (410) 550-2843 x 146

Fax Number:   (410) 550-1535

 

Molecular Neurobiology Research Branch

NIDAIRP

333 Cassell Drive, Suite 3510

Baltimore, MD 21224

Room:

guhl@intra.nida.nih.gov

 

 

Complex Genetics of Addictions and Related Phenotypes

    

The Molecular Neurobiology Branch has developed and used genome wide association and other approaches to identify allelic variants that influence addiction and related phenotypes. Other phenotypes of current interest include ability to quit smoking, cognitive abilities, brain volumes, pain, Alzheimer’s and Parkinson's diseases in humans and in mouse models. Recent work has fostered the working hypothesis that allelic variants in gens including those that encode cell adhesion molecules provide individual differences in the development and/or plasticity of the brain that confer parts of the common genetic vulnerabilities to a variety of complex brain disorders.  We also remain interested in following up prior successes in identifying the genes that encode drug and neurotoxin target sites and genes that are regulated by abused substances.



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