David Linden - Recent Papers

Bangash, M.A., Park, J.M., Melnikova, T., Wang, D., Jeon, S.K., Lee, D., Syeda, S., Kim, J., Kouser, M., Schwartz, J., Cui, Y., Zhao, X., Speed, H., Kee, S., Tu, J.C., Petralia, R.S., Linden, D.J., Powell, C., Savonenko, A., Xiao, B. and Worley, P.F. (2011).  Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism. Cell, in press.

Schonewille, M., Gao, Z., Boele, H., Vinueza Veloz, M.F., , Amerika, W.E., Simek, A.A.M., De Jeu, M.T.G., Steinberg, J.P., Takamiya , K., Hoebeek, F.E., Linden, D.J.,  Huganir, R.H. and De Zeeuw, C.I. (2011).  Re-evaluating the role of LTD in cerebellar motor learning. Neuron, 70, 43-50.

Linden, D.J. (2011)  The Compass of Pleasure.  Viking Press, New York [Link to book website and blog]

Smith-Hicks, C., Xiao, B., Deng, R., Ji, Y., Shepherd, J.D., Kuhl, D., Huganir, R.L.,  Ginty, D.D., Worley, P.F., Linden, D.J. (2010)..  SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of cerebellar LTD.   Nature Neuroscience 13;1082-1089

Hu, J.-H., Park, J.M., Park, S., Xiao, B., Dehoff, M.H., Kim, S., Schwarz, M., Huganir, R., Seeburg, P.H., Linden, D.J. and Worley, P.F. (2010)  Homeostatic scaling requires group I mGluR activation mediated by Homer 1a.  Neuron 68, 1128-1142.

Zhang W, Linden DJ. (2009)  Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude. J Neurosci. 2009 Dec 9;29(49):15586-94.

Kim YS, Shin JH, Hall FS, Linden DJ. (2009)  Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.  J Neurosci. 2009 Jul 1;29(26):8530-8.

Shin, J.H., Kim Y.S. and Linden, D.J. (2008).  Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the USA 105, 746-750.  [PDF]

Cho, R.W., Park, J.M., Wolff, S.B.E., Xu, D., Hopf, C., Reddy, R., Petralia, R.S., Perrin, M.S., Linden, D.J. and Worley P.F. (2008).  mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.  Neuron 57, 858-871.  [PDF]

Kim, S.J., Kim, J., Shin, J.H., Worley, P.F. and Linden, D.J. (2008).  Transient upregulation of postsynaptic IP3-gated Ca release underlies short-term potentiation of mGluR1 function in cerebellar Purkinje cells. Journal of Neuroscience 28, 4350-4355.  [PDF]

Takamiya, K., Mao, L., Huganir, R.L. and Linden, D.J. (2008).  The GRIP family of GluR2-binding proteins is required for LTD expression in cerebellar Purkinje cells.  Journal of Neuroscience 28, 5752-5755.  [PDF]

Park, S., Park, J.M., Kim, S., Kim, J.-A., Shepherd, J.D., Smith-Hicks, C.L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A.G., Huganir, R.L., Linden, D.J. and Worley, P.F. (2008). Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.  Neuron 59, 70-83. [PDF]

Linden, D.J. (2007)  The Accidental Mind: How Brain Evolution Has Given Us Love, Memory Dreams and God.  Belknap Press of the Harvard University Press. Cambridge, MA. [Link to Book Website and Blog]

Nishiyama, H. and Linden, D.J. (2007). Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. Neuron 56, 472-487.  [PDF]

Kim, S.J. and Linden, D.J. (2007)  Ubiquitous plasticity and memory storage.  Neuron 56, 582-592.  [PDF]