David Linden - Recent Papers

Kim YS, Kang E, Makino Y, Park S, Shin JH, Song H, Launay P, Linden DJ. (2013) Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells. Journal of Neurophysiology, 109(4):1174-81. Epub 2012 Nov 28. [pdf]

He L, Linden DJ, Sapirstein A. (2012) Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices. PLoS One. 7(8):e42194. Epub 2012 Aug 2. [pdf]

Linden D.J. (2012) A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis.  J Neurophysiol. 2012 Jan; 1071):448-54. Epub 2011 Nov 2. [pdf]

Schonewille, M., Gao, Z., Boele, H., Vinueza Veloz, M.F., , Amerika, W.E., Simek, A.A.M., De Jeu, M.T.G., Steinberg, J.P., Takamiya , K., Hoebeek, F.E., Linden, D.J.,  Huganir, R.H. and De Zeeuw, C.I. (2011).  Re-evaluating the role of LTD in cerebellar motor learning. Neuron, 70, 43-50. [pdf]

Linden, D.J. (2011)  The Compass of Pleasure.  Viking Press, New York [Link to book website and blog]

Smith-Hicks, C., Xiao, B., Deng, R., Ji, Y., Shepherd, J.D., Kuhl, D., Huganir, R.L.,  Ginty, D.D., Worley, P.F., Linden, D.J. (2010)..  SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of cerebellar LTD.   Nature Neuroscience 13;1082-1089

Hu, J.-H., Park, J.M., Park, S., Xiao, B., Dehoff, M.H., Kim, S., Schwarz, M., Huganir, R., Seeburg, P.H., Linden, D.J. and Worley, P.F. (2010)  Homeostatic scaling requires group I mGluR activation mediated by Homer 1a.  Neuron 68, 1128-1142. [pdf]

Zhang W, Linden DJ. (2009)  Neuromodulation at single presynaptic boutons of cerebellar parallel fibers is determined by bouton size and basal action potential-evoked Ca transient amplitude. J Neurosci. 2009 Dec 9;29(49):15586-94.

Kim YS, Shin JH, Hall FS, Linden DJ. (2009)  Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells.  J Neurosci. 2009 Jul 1;29(26):8530-8.

Shin, J.H., Kim Y.S. and Linden, D.J. (2008).  Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the USA 105, 746-750.  [PDF]

Cho, R.W., Park, J.M., Wolff, S.B.E., Xu, D., Hopf, C., Reddy, R., Petralia, R.S., Perrin, M.S., Linden, D.J. and Worley P.F. (2008).  mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE.  Neuron 57, 858-871.  [PDF]

Kim, S.J., Kim, J., Shin, J.H., Worley, P.F. and Linden, D.J. (2008).  Transient upregulation of postsynaptic IP3-gated Ca release underlies short-term potentiation of mGluR1 function in cerebellar Purkinje cells. Journal of Neuroscience 28, 4350-4355.  [PDF]

Park, S., Park, J.M., Kim, S., Kim, J.-A., Shepherd, J.D., Smith-Hicks, C.L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A.G., Huganir, R.L., Linden, D.J. and Worley, P.F. (2008). Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.  Neuron 59, 70-83. [PDF]

Linden, D.J. (2007)  The Accidental Mind: How Brain Evolution Has Given Us Love, Memory Dreams and God.  Belknap Press of the Harvard University Press. Cambridge, MA. [Link to Book Website and Blog]

Nishiyama, H. and Linden, D.J. (2007). Axonal motility and its modulation by activity are branch-type specific in the intact adult cerebellum. Neuron 56, 472-487.  [PDF]