Johns Hopkins University, Department of Neuroscience
 

 

 

 

Ahmet  Hoke, M.D., Ph.D.


Associate Professor of Neurology and Neuroscience

Director of Neuromuscular Division

Telephone Number:   410-955-2227
Fax Number:   410-502-5459


Johns Hopkins Hospital

600 N. Wolfe St.

Baltimore, MD 21287

Room:  Path 509

ahoke@jhmi.edu

 

Neurobiology of peripheral neuropathies; development and regeneration of the peripheral nervous system

My laboratory is interested in basic biology of peripheral axons and Schwann cells and disorders affecting the peripheral nervous system. We use in vitro and in vivo models of peripheral neuropathies (HIV-associated sensory neuropathies and toxic neuropathies) to study the mechanism of axonal damage and develop therapeutic targets for drug development. In addition, we have more basic research focusing on mechanisms of axonal degeneration and regeneration using in vitro and in vivo models. We utilize engineered stem cells as therapeutic gene delivery tools to promote axonal regeneration in chronically denervated nerves as seen in many degenerating disorders of the peripheral nervous system such as amyotrophic lateral sclerosis and inherited neuropathies.



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